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L-Carnitine is a biologically active amino acid derivative that has a key role in the regulation of fatty acid metabolism and adenosine triphosphate formation in multiple organs

LC and acetyl- L -carnitine (ALC), the two primary types of carnitine used in dietary supplements, come in dosages ranging from roughly 3 mg to 5,000 mg

conducted the present pilot study [2] to examine the ratio of acylcarnitines to free carnitines (AC/FC), a biomarker of cardiomyocyte carnitine insufficiency and impaired -oxidation [3], either in symptomatic HF with reduced left ventricular ejection fraction (LVEF) HFrEF or HF with preserved LVEF (HFpEF), and demonstrated that AC/FC levels in admission were significantly higher than in asymptomatic staged HF, decreasing to comparable levels at discharge

When unabsorbed L-carnitine reaches the large intestine (often due to taking too large of a single dose), certain gut bacteria can metabolize it into a compound called trimethylamine (TMA)

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