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Animals were pre-selected into groups to ensure homogeneous performance

The expression trend of different CYP isoforms was different before and after treatment in psoriasis patients, some clinical trials show that there is a change of CYP450s as a consequence of drug interaction including psoriasis (NCT02993471, NCT02397382 and NCT03718884), suggesting that P450s may be therapeutic targets and provide new ideas for the treatment of skin diseases