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Therapeutic strategies must account for this diversity, either through combination approaches effective against multiple metabolic subtypes or through sequential therapies targeting different populations [77, 78]

-unsaturated aldehydes (alkenals) like acrolein are highly reactive with lysine, cysteine, and histidine through a Michael-type addition as well as with serine, histidine, arginine, threonine, and lysine residues [37, 38]

130 The AuS binding is a well-known covalent bond where thiol groups (soft Lewis base) readily adsorb onto the reduced gold surface (soft Lewis acid) based on the Hard and Soft Acid and Base (HSAB) theory

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Peptide Form: Peptides in powder form are generally more stable than those in solution