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Current experimental datasets from animal studies do not show tumor-promoting effects in laboratory conditions, though theoretical considerations regarding angiogenesis pathway modulation exist in research literature

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Both estrogen receptor alpha and estrogen receptor beta agonists enhance cell proliferation in the dentate gyrus of adult female rats

The relationship between BBB integrity and the gut microbiota is evident in germ free mice models which lack a microbiota and have increased BBB permeability and altered tight junction protein expression effects, which continue from in utero into adulthood [147]

This will require a shift in our thinking