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Anti-Inflammatory Reduces scalp micro-inflammation, which is a known trigger for telogen effluvium and thinning

Adjacent human safety: Increlex (mecasermin) FDA label 71 pediatric patients with severe primary IGFD treated for a mean of 3.9 years

The exact mechanism behind these effects is not well characterized (20)

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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]