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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

CAT is another antioxidant enzyme the activity of which can be affected by Pb, because the latter inhibits the synthesis of heme, which is a basic component in the structure of this antioxidant enzyme (34)

However, recent advancements in research and technology have significantly improved our understanding and management of these conditions

Studies indicate that cells will make a glycolytic switch when NAD + demand is high and exceeds ATP demand, therefore skewing the NAD + use for this pathway 341