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84,85 One complicating factor in clinical trials is the use of progesterone in combination with estrogen: while natural progesterone may augment the neuroprotective effects of estrogen, synthetic progestins such as medroxyprogesterone acetate (MPA) (which are typically used with estrogen in postmenopausal hormone therapy) appear to have the opposite effect

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If your exercise program incorporates a lot of moderate to high intensity activity, or your goal is to build muscle, then supplementation would be beneficial