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For instance, upregulation of the SSP is driven by the AMP-activated protein kinasemTORC1 axis, leading to elevated S-adenosylmethionine (SAM) production and increased expression of DNA methyltransferases, thereby promoting oncogenic transformation of primary pancreatic ductal epithelial cells ( In hepatocellular carcinoma (HCC), USP10 activates liver kinase B1 (LKB1) through deubiquitination

Furthermore, the heterogeneity and complexity of ASD reflect both in the variability of behavioral profiles among affected individuals and in the behavioral changes that may occur within the same individual over time

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The supernatant was transferred to MS vial for LC-MS analysis

The trials were overseen by a friend, Scottish physician Ewan Cameron