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IV administration may also not be sustainable for the long term (Tenrio et al

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mature miR-34a will repress snail expression, which is reported to facilitate HCC cells invasiveness and epithelial-mesenchymal transition ( 4.3 Metabolites A serum biomarker model containing tryptophan, glutamine, and 2-hydroxybutyric acid based on capillary electrophoresistime-of-flight mass spectrometry is established to diagnose HCC from non-HCC, which is confirmed to be an effective biomarker that compensatory for AFP (Zeng et al., 2014)

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along with the DBD, contains a ligand dependent nuclear localization signal [62] E ) Ligand binding domain (LBD) containing activation function 2 (AF-2), responsible for agonist induced activity (activity in the presence of bound agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) [58] A ligand dependent nuclear export signal [63] F ) C-terminal domain Splice variants [edit] AR-V7 is an androgen receptor splice variant that can be detected in circulating tumor cells of metastatic prostate cancer patients [64] [65] and is predictive of resistance to some drugs (caused by missing Ligand-binding domain in this splice variant)