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Furthermore, high concentrations of 4-HNE can cause cell necrosis (217)

Associations of bedroom PM(2.5), CO(2), temperature, humidity, and noise with sleep: An observational actigraphy study

Systemic inflammation and oxidative stress in Hemodialysis patients are associated with down-regulation of Nrf2

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This was accompanied by a significant increase in Nrf2 activity and HO-1 expression, and the effects observed were more potent than hemin (106), a synthetic mimic of heme which is not suitable for clinical use