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2018;115(7):E15309

Moreover, microglia return to their resting morphology after systemic bacterial infection, even though the brain shows elevated proinflammatory mediators, including INF-, IL-1, and IL-12 (Puntener et al., 2012), suggesting microglial inflammatory responses are not fully resolved and remain in a primed state that can augment microglial responses in the context of subsequent stimuli

Sources and references Vitamin B12 - Health Professional Fact Sheet Vitamin B12 - Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline Vitamin B12 Supplementation Adequacy in Australian Vegan Study Participants - PMC Vitamin B12 (Cobalamin) - StatPearls - NCBI Bookshelf Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation