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Excess iron can damage the liver, heart and pancreas in these conditions [31] [35]

Finally, the target genes of miR-100-5p were screened and the mechanism of anti-liver fibrosis was further explored

Conclusions Our study reveals SLC25A39 as a critical regulator of HCC progression via the mitochondrial ROS-cytochrome c -caspase signaling axis, highlighting its potential as a diagnostic biomarker and therapeutic target in HCC