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Genetic toxicology testing returned negative results across multiple assays

Moens AL, Vrints CJ, Claeys MJ, Timmermans J-P, Champion HC, Kass DA

The zebrafish embryonic vascular system is highly conserved evolutionarily, and its functional circulatory system can be constructed within 24 hours after fertilization ( in vitro developmental characteristics of the embryo ( 2 Establishment of zebrafish breast cancer model Conventionally, genetically engineered murine (GEM) models and human cancer cell-derived xenograft models in immunodeficient strains (e.g., NOD-SCID) ( Zebrafish cancer models are constructed using three main strategies: genetic engineering modification, chemically induced carcinogenesis and xenograft models

doi:10.1016/j.ophtha.2019.12.031

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