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Thyroid hormones, particularly triiodothyronine (T3) and thyroxine (T4), are transported across the bloodbrain barrier (BBB) by specialized carriers and are metabolically activated or inactivated by local deiodinase enzymes ( Current therapeutic paradigms focus primarily on pharmacological hormone replacement, most commonly levothyroxine (27)

Science 277 , 11091113 (1997) Schuller, U

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This suggests that DHYZ may alleviate depressive symptoms while inhibiting ferroptosis by modulating the P53/SLC7A11/GPX4 signaling pathway in brain tissue, consequently reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) (Yang et al., 2024)