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These changes have been associated with elevated concentrations in inflammatory markers that correlate with disease severity [8]

Although cytosolic thioredoxin, encoded by TRX2 , is the most important enzyme required for defense against externally added hydroperoxides, cytosolic glutaredoxin, encoded by GRX2 , also contributes to resistance to hydroperoxides ( S

N-acetylcysteine (NAC), alpha-lipoic acid, and B-complex vitamins have more clinical evidence for antioxidant support

Diabetic foot: current status and future prospects

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