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However, in a highly oxidizing environment, the oxidized form of -synuclein cannot be efficiently degraded, resulting in its accumulation and aggregation [78]

e.g., parathion, chlorpyrifos

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Evaluation of 64 brain lesions from 14 patients with clinically diagnosed and neuropathologically confirmed MS revealed increased NQO1 expression in macrophages and astrocytes within active and chronically active demyelinated lesions