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Besides, enhanced IL-8 levels were associated with shorter PFS, while low Ang-2 serum levels were related to improved OS in tumor patients undergoing angiogenesis blockade therapy [90]

NNMT is upregulated in white adipose tissue in obesity and in cancer cachexia models, and NNMT enzymatic activity has been implicated in maintaining the adipocyte fat-storage phenotype through SAM-dependent epigenetic remodeling