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Effect of glutathione depletion on Glutathione S-Transferase and Glutathione reductase activities In view of the major changes induced DEM but not BSO on cell proliferation we determine GST and GR activity in 3T3 fibroblasts (table 1 and table 2, respectively, supplementary data)

The primary antioxidant defense in cells is mediated through enzymatic and non-enzymatic systems, including factors such as glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) (Mourente et al., 2002)

Statistical Analysis Sample size calculations were performed at the beginning of this exploratory trial ( n = 40)

Advanced oxidation protein products (AOPPs) were identified in the plasma of uremic patients by Witko-Sarat et al

Mitophagy decline in aging hearts [12] and impaired PINK1/Parkin-mediated mitophagy in AD [13, 14] lead to damaged mitochondrial accumulation