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and 3) the absence of correlation between genotype and phenotype does not allow a prognosis to be made or change the approach to follow-up.62,63 Set against this opinion is the day-to-day reality of physicians who attend children with NF1: worried parents (who are perfectly informed about the risks and worst aspects of the disease) who want to know for sure whether their child has the disease

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Absolute amounts were calculated from linear calibration curves that were created by serial dilution of synthetically prepared lactyl-CoA