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1.Biosynthesis of Eicosanoids Eicosanoids are synthesized through the enzymatic oxidation of polyunsaturated fatty acids (PUFAs), primarily arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)

The systematic profiling of small molecules reflecting dynamic metabolic states is emerging as a powerful tool in the search for biomarkers in neurodegenerative diseases