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Promoting parthanatos in tumor cells by augmenting PARP-1 activity can impede tumor cell proliferation

It serves as a primary defender against oxidative stressa state where unstable molecules called free radicals outnumber the body's antioxidants

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Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS et al

Besides, it was found that KDM expression was upregulated in various cell models including lung, breast, colorectal and melanoma ones, and treatment of tumour cells with KDM inhibitors resulted in increased overall levels of histone methylation and a significant reduction in the number of DTCs