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360,361 Third, long-term use of SSRIs can increase 5-HT transmission in the LC, 362 thereby increasing the release of GABA to exert inhibitory effects on NA neurons

10.1111/1440-1681.13257 138 ZhangY.YeS.LuW.ZhongJ.LengY.YangT.et al (2023)

459, pp

Consistency matters more than perfectionoccasional missed doses dont negate long-term metabolic adaptation

Therefore, more selective SLC7A11 inhibitors and genetic targeting strategies, including small interfering RNAs (siRNA) and small guide RNAs (sgRNA), would be ideal for clinical purposes