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To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity

Ethics statement The studies involving human participants were reviewed and approved by the Ethics Committee at Henan Provincial Peoples Hospital, Zhengzhou University

Using an AKT activator (SC-79) and an AMPK inhibitor (HY-151361) to simulate the over activation of tumor pathways, we observed a significant increase in the precursor and active forms of SREBP2 (Fig

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