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Targeting p38 MAPK inactivation is another key strategy for remitting renal structural atrophy and fibrosis induced by renal artery stenosis (154)

Pyruvate is capable of doing this both intracellularly as well as extracellularly as it is the sole ketoacid that is secreted

Biotechnol Bioeng 55(6):854863 Hayhurst A (2000) Improved expression characteristics of single-chain Fv fragments when fused downstream of the Escherichia coli maltose-binding protein or upstream of a single immunoglobulin-constant domain