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Fillers, Thread Lifts, Non-Surgical Skin Tightening treatments (Ultherapy, Sofwave, Thermage, Exillis Ultra), and Plastic Surgery (facelift or fat transfer filling) are all options to eliminate smile lines

C., Trenkwalder, C

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The predicted inhibitor-binding mode of 1j with an orientation and conformation that favors most negative docking score when superimposed with the endogenous substrate NCA of the NNMT enzyme indicated that the analog binds consistent with the binding mode of NCA, i.e., the N1-atom of both ligands aligned almost identical, conferring similar molecular interactions with key residues within the active site of the enzyme

In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b