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Marjanska M, McCarten JR, Hodges JS, Hemmy LS, Terpstra M

However, in hepatic GSH-depleted mice, although decreased lipogenesis was observed, we did not observe increased fatty acid oxidation

3 The involvement of NOX-regulated signaling pathways in the development and progression of DCM As diabetes progresses, excessive activation of NOX induces oxidative stress in cardiac cells, which affects cardiac function and structure through multiple signaling pathways

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This gives the cells the potential to achieve higher cellular GSH levels than would otherwise be possible