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However, the liver of mice injected with Mn/TI@mHSA showed significant fluorescence signals at 24 h post-injection, which was stronger than that in the P-Mn/TI@mHSA group

Selection among these quantitative approaches depends on experimental design, sample characteristics, required analytical depth, and quantitative precision needs

meaning that animal studies have shown some adverse effect or there are no well-controlled studies in humans, but potential benefits may warrant use despite potential risks

Funding This project was funded by the NIH P01 AG001751 to DJM and R15 AG055077 to TT

However, at supra-nutritional concentrations, SeNPs exert cytotoxic effects by inducing cell cycle arrest and triggering apoptotic pathways [45]