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Specifically, lactylation is deposited on the activity enhancers in the NCC gene regulatory network, promoting chromatin accessibility and influencing NCC behavior like migration

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For instance, lactylation of K508 on NSUN2, a typical methyltransferase responsible for RNA m 5 C modification, enhances its activity, facilitating GCLC m 5 C methylation and stabilizing GCLC mRNA, which enhances GSH production and reduces oxidative stress, thereby promoting gastric cancer cell survival