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It is a commonly accepted fact that wounds in diabetic patients exhibit decreased levels of angiogenic factors, resulting in impairment of angiogenesis [128, 129]

Upon entering the vessel lumen, NO inhibits the activation of IIb3 integrins in platelets, suppresses platelet aggregation [76,77] , and obstructs the adhesion of inflammatory cells to the vessel endothelium [78]

Conversely, ULK1 and 2 activities can be blocked by copper depletion with a high affinity copper chelator

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It is suspected that Osler himself died of complications from undiagnosed bronchiectasis