glutathione gstm1 Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation Glutathione: Master Antioxidant, Reducing Oxidative

doi: 10.3389/falgy.2024.1365801 Received 05 January 2024 Accepted 07 March 2024 Published 18 March 2024 Volume 5 - 2024 Edited by Hayley Scott, The University of Newcastle, Australia Reviewed by Kimberley Choon Wen Wang, University of Western Australia, Australia Ulrich Matthias Zissler, University Hospital rechts der Isar, Technical University of Munich, Germany Updates Copyright 2024 Listyoko, Okazaki, Harada, Inui and Yamasaki

Notably, a 40-year-old woman in the study who received 500 mg DSF per day discontinued DSF therapy after 2.6 months of treatment due to motor neuropathy

Feng T, Ahmed W, Ahmed T, Chen L

But also, intermittent exposure left GSH unchanged in TM3 cell and in GC-1 cell, in line with previous reports that only certain exposure paradigms perturb glutathione balance

They found that combining ATO with a p97 inhibitor (an ATPase involved in protein quality control) dramatically sensitizes these cells [315]