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Although thyroid hormone production in follicular cells is iron-dependent, iron overloadresulting from hepcidin-mediated ferroportin blockade, macrophage-derived ferritin uptake, and heme catabolismand resultant oxidative stress can trigger their degeneration through the ferroptosis pathway (179)

Disclosure of interest: Nothing to disclose Poster Session I - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.03 - PROGNOSIS AND OUTCOME AFTER STROKE P251 - ESOC25-1888 INCIDENCE, CHARACTERISTICS AND CONSEQUENCES OF FRACTURES AFTER ACUTE ISCHEMIC STROKE AND TIA A PROSPECTIVE COHORT STUDY Benjamin Dejakum 1,2 , Anel Karisik 1,2 , Kurt Mlgg 1,2 , Julian Granna 2 , Silvia Komarek 1 , Raimund Pechlaner 1 , Lukas Mayer-S 1 , Thomas Tll 1 , Lucie Buergi 2 , Lukas Scherer 2 , Karin Christine Willeit 1 , Martin Heidinger 3,4 , Heinrich Resch 5 , Clemens Lang 4,6 , Julia Ferrari 7 , Stefan Krebs 7 , Rainer Kleyhons 8 , Johann Willeit 1 , Lisa Seekircher 9 , Lena Tschiderer 9 , Peter Willeit 9,10 , Marek Sykora 7,11 , Georg Schett 12,13 , Wilfried Lang 2,14 , Michael Knoflach 1,2 , Stefan Kiechl 1,2 , Christian Boehme 1 1 Medical University Innsbruck, Innsbruck, Austria, 2 VASCage, Innsbruck, Austria, 3 University of Basel, Basel, Switzerland, 4 Depatment of Orthopaedic Surgery and Traumatology, Clinic Donaustadt, Vienna, Austria, 5 Metabolic Bone Diseases Unit, Sigmund Freud University Vienna, School of Medicine, Vienna, Austria, 6 Ludwig Boltzmann Institute Traumatology, Research Center in Cooperation with AUVA, Vienna, Austria, 7 St

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