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miR-144 is the first miRNA identified as an Nrf2 negative regulator (Sangokoya et al., 2010), and miR-144 can also promote autophagy (Sun et al., 2019)

Results Preparation of rhGPx3 mutant The hGPx3 mutant gene was cloned into expression vector pCold I for preparation of selenium-containing rhGPx3 mutant in E