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Additionally, the nuclear transcription factor (Foxo1) is phosphorylated upon activation of phosphoinositide- 3-kinaseprotein kinase B/Akt (PI3 K-PKB/Akt), which in turn deactivates molecules to restrict the activity of proapoptotic pathways [66]

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Funding: This manuscript was supported in part by an unrestricted grant from the Peritz and Chantal Scheinberg Cerebrovascular Research Fund

A glucose load (2 g/kg body weight) was given to each rat orally with a feeding syringe