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The EtOAc layer was separated, dried with MgSO 4 , filtered, adsorbed to silica and purified by silica gel flash column chromatography (15 min, 0 30% v/v EtOAc/hexanes) to produce pure 4-chloro-1-((4-nitrophenyl)sulfonyl)piperidine (0.29 g, 0.96 mmol, 96% yield)

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doi: 10.1016/j.redox.2021.101950 83 ZhongBYuJHouYAiNGeWLuJJet al

Addresses of the service centres are as follows (appointments must be made through the hotline first): Room 1501, 15/F, AT Tower, 180 Electric Road, North Point Rooms 1805-06, 18/F, Wu Sang House, 655 Nathan Road, Mong Kok Room 1606, 16/F, Futura Plaza, 111 How Ming Street, Kwun Tong Wan Tau Tong Neighbourhood Community Centre, Wan Tau Tong Estate, Tai Po 1/F, Yuen Long District Sports Association Jockey Club Complex, 8 Yuen Long Tai Yuk Road, Yuen Long Service hours of the service centres: During application period (March 23 to April 12): 9am to 6pm from March 23 to April 8 9am to 8pm from April 9 to April 11 9am to 10pm on April 12 Applicants must provide true, complete and accurate information in the application form

In addition to this, bile actually stimulates two very important receptors referred to as FXR and TGR5