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Evidence-based guide to peptide therapy for joint health

77,78 The extracellular and intracellular cystine and glutamate concentrations keep the function of system Xc to protect cells in an antioxidant state

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Because spermidine is not only obtained from the diet but is also endogenously synthesised and produced by the gut microbiota, the total polyamine pool reflects the combined contribution of all three sources, making it difficult to detect a shortage from any single source, and therefore true dietary depletion conditions are unlikely to occur 9

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