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These would include those who are pregnant or actively breastfeeding, as well as those with specific medical disorders and allergies

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ

PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165

On the other hand, the non-tumorigenic, spontaneously immortalized keratinocyte cell line - HaCaT cells can provide almost unlimited supply of identical cells, ensuring high intra- and inter-laboratory reproducibility

Collagen is a structural protein that maintains skin firmness, elasticity, and prevents wrinkles