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A double-blind, placebo-controlled trial published in Skin Pharmacology and Physiology (Proksch et al., 2014) (2) with 114 women aged 45-65 showed that daily intake of 2.5 g of specific bioactive collagen peptides led to a 20% reduction in eye wrinkle volume and significant increases in dermal matrix proteins like procollagen type I ( +65% ) and elastin ( +18% )

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It was found that the increase in ROS after high-dose vitamin C treatment also induced DNA damage and PARP activation in KRAS or BRAF transformed cells

The acute toxicity of SeNPs is about seven times that of sodium selenite: their LD50s are 113 and 16 mg/kg, respectively