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In addition, a recent study indicated that the active hepatoprotective ingredient tetramethylpyrazine inhibits the activation of RIPK1/RIPK3 necrosome and the phosphorylation of MLKL caused by alcohol intake, and exerts an anti-ALD effect by alleviating necroptosis (Zhou et al., 2022b)

Hormonal imbalances: Fluctuations in hormones like estrogen may influence DAO levels

Given this situation it is particularly concerning that MDA campaigns show that PZQ cure rates are often less than 50% and modeling studies demonstrating that these campaigns with PZQ alone are unlikely to interrupt transmission, and once MDA is suspended, the prevalence of infection is likely to rebound to pre-MDA levels 9,10,11

cicadae S.Z