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The lower proportion of insulin triggers activation of glycogen synthase kinase-3 beta (GSK3B), a multifunctional serine/threonine protein kinase enzyme and ultimately produces hyperphosphorylation of Tau protein and accumulation of neurofibrillary tangles causing CD (Umegaki, 2010)

Those with HHs were older, more obese, and more likely female compared to those without HHs

Cons: Less accurate than blood tests

Acta Crystallogr D Biol Crystallogr

The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound