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In 1990, Wolff et al

Int J Mol Sci 25(7)

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Cellular Defence Helps reduce oxidative damage caused by stress, pollution, or illness

The third family, IGF-1 LR3, skips the GH-signaling step entirely, binding directly to the IGF-1 receptor on muscle tissue and activating the PI3K/Akt and MAPK pathways tied to cell growth