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The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

The plant transcriptome is a complete pool of various RNA molecules (mRNA, rRNA, tRNA, as well as numerous ncRNAs) belonging to the translated fraction of the genome that responds to its environment (Imadi et al., 2015)

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This exhausted state is characterized by a hierarchical loss of cytokine production, cytolytic capacity, and proliferative potential