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These medications do not directly affect this immune response, but rather work to counteract its effects by increasing acetylcholine levels

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Gastrointestinal effects dominate the tolerability picture Across the Phase 2 obesity, MASH, and diabetes trials, the most consistent finding is a high rate of gastrointestinal adverse events nausea, vomiting, and diarrhea substantially more frequent than placebo

Different mechanisms of action may be more or less effective depending on variants, for example the degree to which TMPRSS2 contributes to viral entry can differ across variants94,95