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The ergothioneine in porcini appears to buffer the physiological stress that normally amplifies my caffeine intolerance, and it also seems to exert a stabilizing effect on some brain functions

Long F, Lin H, Zhang X, Zhang J, Xiao H, Wang T

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When the production and presence of ROS dominates the antioxidant capacity, cell undergoes oxidative stress, leading to damage to cellular components and causing aging, cancer, neurodegenerative diseases (Davalli et al

Importance of dose adjustments based on lab results and symptoms Dose should tune to both labs and clinical effect