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Ringseis, R., Keller, J

However, resistance to enzalutamide has now also been identified as a result of an Phe876Leu point mutation in the LBD (213) and the expression of NH 2 -terminal domain splice variants (163) in CRPC, emphasizing the need for continued research and development of strategies to switch off androgen receptor signaling

Based on the Vd, you can calculate precisely how much additional phenobarbital is required in a top-up dose to hit the therapeutic target