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Plasma proteomic signature of major depressive episode in the elderly

This metabolic reprogramming not only fulfills the energy demands required for the rapid proliferation of cancer cells but also results in the accumulation of numerous toxic by-products (e.g., methylglyoxal [MG], L-2-hydroxyglutaric acid, and glutaryl coenzyme A) ( It is worth noting that the effect of MG exhibits a prominent dose-dependent dual effect known as hormesis: at low concentrations, MG can induce malignant transformation of normal cells and promote carcinogenesis

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J Exp Med 1992

Food and Drug Administration (FDA) approved