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In humans, the HTMLA activity is partially compensated by serine hydroxymethyl transferase (SHMT) 1 and 2, while in mice, threonine aldolase (Tha1) is the primary source of HTMLA activity, but this gene is absent in humans [159].The liver and kidney are considered the primary organs involved in carnitine synthesis because of their considerable BBD activity

W., Olson, M., Purpura, M., and Jager, R

The protocol consisted of using photodynamic therapy (PDT, via intense pulsed light at 400720 nm, administered in four sessions spaced two weeks apart), combined with a cream containing L-carnitine, licochalcone A, and decanediol, applied twice daily for 10 weeks

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It has not been possible to determine which symptoms are due to carnitine deficiency and which are due to an underlying organic acidemia, as symptoms of both abnormalities may be expected to improve with Levocarnitine