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It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

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Others who may not be able to tolerate dosages of vitamin B12 that are higher than what is found in most multivitamins include people who have been diagnosed with low potassium, Leber's vision loss, or atrophic gastritis, according to WebMD

The net cost comparison depends heavily on bioavailability

Evidence suggests that A can enhance neuronal iron uptake and promote GPX4 degradation, while lipid peroxidation products may accelerate tau hyperphosphorylation