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Wu J, Lei Z, Yu J

In addition, astrocytic connexin channels, which regulate the transport of adenosine triphosphate (ATP), glutamine and glucose, exhibit altered expression patterns in disease states, shifting astrocytes toward either a neuroprotective or neurotoxic metabolic profile 76

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(137) further indicated that DKD microvascular complications are closely associated with abnormal BCAA metabolism, with high levels of L-leucine [area under the curve (AUC) = 0.834] and isoleucine (AUC = 0.932) demonstrating high diagnostic ability in distinguishing DKD from T2DM

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S