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Energy landscape view of proinsulin folding and disulfide pairing

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The SGLT2 inhibitor empagliflozin has a beneficial effect in rotenone-induced zebrafish model of PD [146]

All v.4 targets are included in the v.4.1 assay based on SeqId, and only the v.4 targets were analysed for this study

Combined with peripheral dopa decarboxylase inhibitors in fixed-dose formulations, it is converted into dopamine after crossing the bloodbrain barrier, effectively compensating for the dopaminergic deficit in the nigrostriatal pathway and significantly improving core motor symptoms such as bradykinesia, rigidity, and tremor [100], long-term use is associated with motor complications including wearing-off phenomena, dyskinesias, and "onoff" fluctuations, as well as peripheral dopaminergic adverse effects such as nausea, vomiting, and hypotension [101, 102]