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EMT is a multi-step process in which epithelial cells lose their characteristic traits and gain mesenchymal features, including the loss of cell junctions and apicobasal polarity [33]

112 The cGAS-STING signaling pathway is an innate immune sensing system that is capable of driving both acute and chronic low-grade inflammation, which is central to the development of neurodegenerative pathologies

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Interestingly, the effect of acetaminophen and exercise combination appears dependent on type of exercise as acetaminophen has been reported to suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise (Trappe et al., 2002), which appears to be mediated through decreasing exercise-induced PGF(2alpha) expression and hence affecting the anabolic response of muscle to eccentric resistance exercise (Trappe et al., 2001)